Effect of CO(2) pneumoperitoneum on renal function in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 119-121, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-265682
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of different CO(2) pneumoperitoneum conditions on renal function in rats and provide experimental evidence for improving renal graft function after transplantation.</p><p><b>METHODS</b>SD rats were randomized into 10 groups (n=12) and subject to CO(2) pneumoperitoneum at different pressures (0.67, 1.33 and 2.0 kPa) for 60 or 120 min. Serum urea nitrogen (BUN), creatinine (Cr) and N-acetyl-β-D-glocosaminidase (NAG) levels were detected after pneumoperitoneum.</p><p><b>RESULTS</b>As the pressure and time of pneumoperitoneum increased, the renal function deteriorated gradually, showing significant differences between the groups (P<0.05).</p><p><b>CONCLUSION</b>Increased pressure and prolonged duration of CO(2) pneumoperitoneum causes impairment of the renal function, suggesting the necessity of reducing the operative time and lowering the pressure of pneumoperitoneum when harvesting renal graft in living donors.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Pneumoperitônio Artificial
/
Espaço Retroperitoneal
/
Cirurgia Geral
/
Fatores de Tempo
/
Dióxido de Carbono
/
Transplante de Rim
/
Ratos Sprague-Dawley
/
Laparoscopia
/
Coleta de Tecidos e Órgãos
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2012
Tipo de documento:
Artigo
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