Optimization of a compound prescription for treating liver fibrosis / 南方医科大学学报
Journal of Southern Medical University
; (12): 106-108, 2012.
Article
em Zh
| WPRIM
| ID: wpr-265686
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To optimize a compound prescription for treatment of liver fibrosis with an improved therapeutic effect and low toxicity.</p><p><b>METHODS</b>In rat models of liver fibrosis induced by thioacetamide (TAA), the optimized prescription was screened based on a uniform design with 2-factor 5-level table using Uniform Design 3.0 software and tested using liver content of Hyp as the screening index. To verify the efficacy of the optimized prescription, the rat models of liver fibrosis were randomized into normal control group, model group, colchicine group and optimized prescription group, and the changes of hepatic Hyp content, serum HA, ALT, AST, and ALB levels, and the pathology liver fibrosis were observed after corresponding treatments.</p><p><b>RESULTS</b>The optimized prescription, which contained 70 mg/kg glycyrrhizin and 70 mg/kg matrine, showed a significant therapeutic effect against liver fibrosis in rats (Plt;0.05), and the effect was equivalent to that of colchicine (P>0.05).</p><p><b>CONCLUSION</b>Uniform design is a valuable method in prescription optimization. The optimized compound prescription of matrine and glycyrrhizin has a significant effect in inhibiting liver fibrosis.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Quinolizinas
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Tioacetamida
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Ratos Sprague-Dawley
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Ácido Glicirrízico
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Tratamento Farmacológico
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Quimioterapia Combinada
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Alcaloides
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Cirrose Hepática
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Fitoterapia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2012
Tipo de documento:
Article