Clinical significance of blood and fecal tumor M2-pyruvate kinase expression in patients with colorectal cancer / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the clinical significance of blood and fecal expression of tumor M2-pyruvate kinase (Tumor M2-PK) in patients with colorectal cancer.</p><p><b>METHODS</b>With 22 healthy subjects as controls, 44 patients with CRC were examined for tumor M2-PK in serum and fecal samples using a sandwich enzyme immunoassay.</p><p><b>RESULTS</b>The sensitivity of serum and fecal tumor M2-PK for detecting CRC was 59.1% and 63.6% with a specificity of 86.4% and 81.8%, respectively. The serum and fecal levels of tumor M2-PK showed a significant correlation in CRC patients.</p><p><b>CONCLUSION</b>Tumor M2-PK has good sensitivity and specificity in the diagnosis of CRC.</p>