Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis
Yonsei Medical Journal
;
: 1353-1361, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-26582
ABSTRACT
PURPOSE:
Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC. MATERIALS ANDMETHODS:
All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and CRC risk were identified by searching PubMed and Web of Science. The CRC risk associated with the four polymorphisms of the COX-2 gene was estimated for each study by odds ratio (OR) together with its 95 % confidence interval (CI), respectively.RESULTS:
A total of 15 case-control studies were included. Overall, no evidence has indicated that the -1195A allele, -765C allele, 8473C allele, and 511Ala allele are associated with susceptibility to CRC (-1195G>A OR=1.11, 95 % CI 0.82-1.51, p=0.78; -765G>C OR=1.08, 95 % CI 0.96-1.21, p=0.07; 8473T>C OR=1.03, 95 % CI 0.89-1.18, p=0.91; Val511Ala OR=0.71, 95 % CI 0.46-1.09, p=0.94). However, stratified analysis with ethnicity indicated that individuals with -765GC or GC/CC genotypes had an increased risk of CRC among Asian populations (GC vs. GG OR=1.05, 95 % CI 0.87-1.28, p=0.03; GC+CC vs. GG OR=1.08, 95 % CI 0.96-1.21, p=0.07).CONCLUSION:
This meta-analysis indicated that -765G>C polymorphism was significantly associated with susceptibility to CRC in Asian populations.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Neoplasias Colorretais
/
Estudos de Casos e Controles
/
Predisposição Genética para Doença
/
Povo Asiático
/
Ciclo-Oxigenase 2
Tipo de estudo:
Estudo observacional
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Limite:
Humanos
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
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