Pachymic acid, a novel compound for anti-rejection: effect in rats following cardiac allograft transplantation / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2898-2902, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-266019
ABSTRACT
<p><b>BACKGROUND</b>Pachymic acid (PA), a natural triterpenoid, is known to significantly reduce cell proliferation and induce apoptosis in vitro through initiation of mitochondria dysfunction. However, its effect on immune cells and anti-rejection following organ transplantation remains unknown.</p><p><b>METHODS</b>In this study, we investigated PA as a treatment to control acute rejection occurred in rats which had accepted cardiac transplantation. We measured apoptosis of peripheral blood lymphocyte (PBLs), and CD4(+) lymphocyte, as well as the number of CD4(+) and CD8(+) lymphocytes and the effect of PA on acute rejection in rats 7 days after cardiac transplantation.</p><p><b>RESULTS</b>PA treatment might decrease allograft rejection, protect PBLs from apoptosis, and reduce the percentage of CD8(+) lymphocyte. PA neither regulated the number nor the apoptosis rate of CD4(+) lymphocyte.</p><p><b>CONCLUSIONS</b>Our findings indicated that PA has an anti-apoptotic effect acting on PBLs through a novel mechanism involving stabilization of the PBLs mitochondrial transmembrane potential, an anti-rejection effect in rats after cardiac transplantation and an inhibiting effect to CD8(+) lymphocyte.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transplante Homólogo
/
Triterpenos
/
Linfócitos
/
Transplante de Coração
/
Ratos Wistar
/
Ratos Sprague-Dawley
/
Apoptose
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Potencial da Membrana Mitocondrial
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS