Involvement of Selective Alpha-2 Adrenoreceptor in Sympathetically Maintained Pain
Journal of Korean Neurosurgical Society
;
: 420-423, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-26615
ABSTRACT
OBJECTIVE:
Peripheral nerve injury often leads to neuropathic pain, which is characterized by burning pain, allodynia, and hyperalgesia. The role of the sympathetic nervous system in neuropathic pain is a complex and controversial issue. It is generally accepted that the alpha adrenoreceptor (AR) in sympathetic nerve system plays a significant role in the maintenance of pain. Among alpha adrenoreceptor, alpha-1 receptors play a major role in the sympathetic mediated pain. The primary goal of this study is to test the hypothesis that sympathetically maintained pain involves peripheral alpha-2 receptors in human.METHODS:
The study was a randomized, prospective, double-blinded, crossover study involving twenty patients. The treatments were Yohimbine (30 mg mixed in 500 mL normal saline), and Phentolamine (1 mg/kg in 500 mL normal saline) in 500 mL normal saline at 70 mL/hr initially then titrated. The patients underwent infusions on three different appointments, at least one month apart. Thus, all patients received all 2 treatments. Pain measurement was by visual analogue scale, neuropathic pain questionnaire, and McGill pain questionnaire.RESULTS:
There were significant decreases in the visual analogue scale, neuropathic score, McGill pain score of yohimnine, and phentolamine.CONCLUSION:
We conclude that alpha-2 adrenoreceptor, along with alpha-2 adrenoreceptor, may be play role in sympathetically maintained pain in human.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Agendamento de Consultas
/
Fentolamina
/
Distrofia Simpática Reflexa
/
Sistema Nervoso Simpático
/
Ioimbina
/
Medição da Dor
/
Queimaduras
/
Estudos Prospectivos
/
Inquéritos e Questionários
/
Estudos Cross-Over
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2010
Tipo de documento:
Artigo
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