Effects of Shengmai injection on testicular injury after torsion/detorsion in rats of different ages / 中华男科学杂志
National Journal of Andrology
;
(12): 185-188, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-266192
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the different effects of Shengmai injection on testicular injury after testis torsion/detorsion in rats of different ages.</p><p><b>METHODS</b>Sixteen healthy male SD rats aged 3, 6 and 12 weeks were equally randomized into an experimental group (testicular torsion/detorsion plus Shengmai injection) and a control group (testicular torsion/detorsion plus saline). The rat models of testicular torsion were killed 24 h after surgery for the measurement of total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the testis.</p><p><b>RESULTS</b>Compared with the controls, the 3- and 6-week-old rats of the experimental group showed no significant changes in T-AOC, SOD activity and MDA content (P > 0.05), while the 12-week-old experimental rats exhibited a remarkable increase in SOD and T-AOC and an obvious decrease in MDA content (P < 0.05).</p><p><b>CONCLUSION</b>Shengmai injection has a protective effect against acute ischemia-reperfusion testicular injury after torsion/detorsion in rats, but the effect varies with the age, more obvious in older ones.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Torção do Cordão Espermático
/
Superóxido Dismutase
/
Testículo
/
Ferimentos e Lesões
/
Medicamentos de Ervas Chinesas
/
Traumatismo por Reperfusão
/
Ratos Sprague-Dawley
/
Usos Terapêuticos
/
Combinação de Medicamentos
/
Tratamento Farmacológico
Limite:
Animais
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2011
Tipo de documento:
Artigo
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