Expression of human testis development related gene 1 in testicular cancer detected by tissue microarray / 中华男科学杂志
National Journal of Andrology
;
(12): 883-886, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-266251
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protein expression of human testis development related gene 1 (TDRG1) in human testicular cancer and its pathological significance.</p><p><b>METHODS</b>The expression levels of TDRG1 were detected in the testis tissues of testicular cancer patients and normal men by tissue microarray and immunohistochemistry, and the results were analyzed.</p><p><b>RESULTS</b>Immunohistochemistry exhibited positive expression of the TDRG1 protein in the testis of 73.3% (11/15) of the normal men, 83.3% (10/12) of the patients with embryonal carcinoma, 80.0% (8/10) of those with yolk sac tumor, 26.9% (7/26) of those with seminoma, and 57.1% (4/7) of those with teratoma. The expression levels of TDRG1 in the testis tissues of the seminoma and teratoma groups were shown to be significantly lower than that of the normal control (P < 0.01 and P < 0.05), but those of the embryonal carcinoma and yolk sac tumor groups exhibited no significant differences from that of the latter (P > 0.05).</p><p><b>CONCLUSION</b>The significantly reduced expression of the TDRG1 protein in patients with seminoma or teratoma indicates that TDRG1 may be a candidate cancer suppressor gene.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Testiculares
/
Testículo
/
Dados de Sequência Molecular
/
Estudos de Casos e Controles
/
Regulação Neoplásica da Expressão Gênica
/
Neoplasias Embrionárias de Células Germinativas
/
Proteínas de Homeodomínio
/
Análise Serial de Proteínas
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Criança, pré-escolar
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2010
Tipo de documento:
Artigo
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