Meta analysis on the effectiveness of inactivated influenza vaccine / 中华流行病学杂志

ABSTRACT

Objective To understand the effectiveness of inactivated influenza vaccines (IIV).Methods We did a Meta analysis on IIV effectiveness with papers published during March 1998 and May 2008 in Chinese journals, using fixed model or random model according to the heterogeneity of the studies. Results A total number of 13 studies were included, of which 11 were cohort studies and 2 were randomized controlled trials. Through Meta analysis on cohort studies regarding the effectiveness against influenza like illness (ILI) ,we noticed that the effectiveness of the vaccine was 66% (95%CI51%-76 % ) in children and adolescents, but 47 % (25 %-63 % ) in adults, and 53 % (20%-72%) in the elderly. Conclusion IIV was effective in protecting against influenza like illness.