Studies on formulations of Panax notoginsenosides for intranasal administration / 药学学报
Acta Pharmaceutica Sinica
;
(12): 859-862, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-266567
ABSTRACT
<p><b>AIM</b>To develop high bioavailability preparations without irritation for Panax notoginsenosides.</p><p><b>METHODS</b>The effects of some additives such as microcrystalline cellulose, beta-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined.</p><p><b>RESULTS</b>Saponins of Panax notoginseng (PNS) was absorbed in rabbits more when administered intranasally than through other routines, and the formulations including MCC both gave high bioavailability and low irritation.</p><p><b>CONCLUSION</b>Bioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Permeabilidade
/
Bufo bufo
/
Administração Intranasal
/
Portadores de Fármacos
/
Farmacocinética
/
Disponibilidade Biológica
/
Celulose
/
Química
/
Sistemas de Liberação de Medicamentos
/
Ciclodextrinas
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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