NMR studies on cetirizine hydrochloride / 药学学报
Acta Pharmaceutica Sinica
;
(12): 767-770, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-266607
ABSTRACT
<p><b>AIM</b>To study the NMR phenomena of cetirizine hydrochloride and assign all proton and carbon signals in NMR spectra.</p><p><b>METHODS</b>To record the 1D and 2D NMR spectra of cetirizine hydrochloride while changing the experimental temperature and adding D2O into the solution.</p><p><b>RESULTS</b>More than one NMR signal or broad peak resulting from piperazine and the attached groups with N atom were given in DMSO-d6 solution at room temperature. "Coalescence" or narrowing had occurred for the proton and carbon signals when the experimental temperature was increased or D2O was added into the solution.</p><p><b>CONCLUSION</b>Compared with the NMR "time scale", there are more than one conformation of cetirizine hydrochloride in DMSO-d6 solution at room temperature. The different conformation will be exchanged fast while temperature rise and the stable conformation will be existed while D2O was added into the solution.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Conformação Proteica
/
Temperatura
/
Espectroscopia de Ressonância Magnética
/
Estrutura Molecular
/
Química
/
Cetirizina
/
Deutério
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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