Cutaneous permeation kinetics and pharmacodynamics of topical lidocaine gel in rat / 药学学报
Acta Pharmaceutica Sinica
;
(12): 631-633, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-266620
ABSTRACT
<p><b>AIM</b>To study the cutaneous permeation kinetics and pharmacodynamics of lidocaine gel.</p><p><b>METHODS</b>The concentration of lidocaine in dermis following topical application in rats was determined by the cutaneous microdialysis technique and related parameters were calculated; the pharmacodynamics of the gel was evaluated by electric stimulation method with EMLA (eutectic mixture of local anesthetics) cream as a control.</p><p><b>RESULTS</b>The peak of percutaneous absorption kinetic profile of lidocaine gel across rat skin occurred at 1.25 h; the onset time of local anesthetic action of lidociane gel was similar to that of EMLA, but both the duration and depth of anesthetic effect were superior to EMLA cream.</p><p><b>CONCLUSION</b>Lidocaine gel showed good anesthetic effect. The minimum effective concentration of lidocaine in dermis is 12 mg.L-1.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Prilocaína
/
Absorção Cutânea
/
Farmacocinética
/
Distribuição Aleatória
/
Ratos Wistar
/
Limiar da Dor
/
Géis
/
Anestesia Local
/
Anestésicos Locais
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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