Kidney-targeting characteristics of N-acetyl-L-glutamic prednisolone prodrug / 药学学报
Acta Pharmaceutica Sinica
;
(12): 627-630, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-266621
ABSTRACT
<p><b>AIM</b>To study the in vivo distribution of N-acetyl-L-glutamic prednisolone (ACEP) and to investigate the renal targeting characteristics of the prodrug.</p><p><b>METHODS</b>The concentrations of prednisolone in organs at predetermined time were assayed by HPLC after intravenous administration of ACEP or prednisolone to Kunming mice. The adverse effects were evaluated by testing the bone mineral densities (BMD) of Wistar rats.</p><p><b>RESULTS</b>The concentrations of prednisolone in kidney 15 min after i.v. administration were (86 +/- 8) microgram.g-1 for ACEP group, (57 +/- 4) microgram.g-1 for prednisolone group; 60 min after i.v. administration were (67 +/- 5) microgram.g-1 for ACEP group, (42 +/- 4) microgram.g-1 for prednisolone group. BMDs were (0.08 +/- 0.03) g.cm-2 and (0.14 +/- 0.06) g.cm-2 for prednisolone and ACEP-treated Wistar rats respectively.</p><p><b>CONCLUSION</b>Compared with the parent drug prednisolone, ACEP has kidney-targeting behavior and lower toxicity (n = 5, P < 0.001).</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prednisolona
/
Farmacocinética
/
Pró-Fármacos
/
Absorciometria de Fóton
/
Densidade Óssea
/
Sistemas de Liberação de Medicamentos
/
Ratos Wistar
/
Rim
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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