Studies on the simvastatin effect on the artery of atherosclerotic rabbit using proteomics approaches / 药学学报
Acta Pharmaceutica Sinica
;
(12): 511-514, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-266649
ABSTRACT
<p><b>AIM</b>To evaluate the inhibitory effect of simvastatin via investigating the overall expression level of proteins in the artery of atherosclerotic rabbit.</p><p><b>METHODS</b>Experimental model was established by feeding the rabbits a high fat diet (cholesterol 0.5 g.kg-1.d-1, lard 0.5 mL.kg-1.d-1) for 8 weeks. Then simvastatin (5 mg.kg-1) were fed for 4 weeks to the rabbits. The overall protein levels were measured using two-dimensional gel electrophoresis and a PDQUEST data processing.</p><p><b>RESULTS</b>Twenty nine protein spots showed significant quantitative changes in comparison with the normal and the diseased rabbits. Furthermore, after the diseased rabbit having taken simvastatin, an obvious decay of symptom of fatty liver was observed, and the intensity of most spots has not been back-regulated.</p><p><b>CONCLUSION</b>Simvastatin facilitates the metabolism of fat in the blood, but the lesion of the internal wall of the atherosclerotic artery cannot be restored.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Artérias
/
Arteriosclerose
/
Proteínas
/
Distribuição Aleatória
/
Sinvastatina
/
Usos Terapêuticos
/
Dieta Aterogênica
/
Tratamento Farmacológico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Artigo
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