Laboratory study of the yi-fu-ning soft gelatin capsules in treating climacteric syndrome / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 253-257, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-266773
ABSTRACT
<p><b>OBJECTIVE</b>To study the therapeutic mechanism of YFN on climacteric syndrome by investigating the effect of Yi-Fu-Ning soft gelatin capsules (YFN), which can nourish the kidney and activate blood, on serum sex hormone levels and hypothalamic monoamine transmitters contents in ovariectomized rats.</p><p><b>METHOD</b>Fifty female mature Sprague-Dawley rats were randomly divided into 5 groupssham operation;ovariectomy(OVX);OVX with diethylstilbestrol tablets(DT);OVX with YFN(high dose and low dose). After drugs had been given for 4 weeks, hypothalamic monoamine transmitters (NE, DA, 5-HT, 5-HIAA) contents were detected by fluorospectrophotometric method and serum sex hormone by radioimmunoassay. Adrenal gland index, uterus index and thymus index were also determined.</p><p><b>RESULT</b>YFN could obviously improve serum E2 and increase adrenal gland and uterus index in OVX rats (P < 0.01 or P < 0.05). It could reduce hypothalamic 5-HT and 5-HIAA, which were increased in OVX rats(P < 0.01); It could also increase reduced NE and DA in OVX rats and reduce the ratio of 5-HT to NE and 5-HT to DA(P < 0.01).</p><p><b>CONCLUSION</b>YFN can regulate procreate endocrine in various ways and ameliorate the function of hypothalamic monoamine neurotransmitter in OVX rats. So it can stabilize inner condition of body and relieve symptoms of climacteric syndrome.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oviductos
/
Farmacologia
/
Ranidae
/
Hormônios Esteroides Gonadais
/
Sangue
/
Climatério
/
Cápsulas
/
Medicamentos de Ervas Chinesas
/
Materia Medica
/
Ovariectomia
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2003
Tipo de documento:
Artigo
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