Effects of Angelica sinensis polysaccharides on hepatic drug metabolism enzymes activities in mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 149-152, 2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-266796
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Angelica sinensis Polysaccharides (ASP) on the hepatic drug metabolism enzymes activities in normal mice and those prednisolone (PSL)-induced liver injury.</p><p><b>METHOD</b>The activities of phase II enzymes (GSH-related enzymes) and cytochrome P450 enzymes were measured by biochemical method.</p><p><b>RESULT</b>ASP increased the activities of glutathione S-transferase in liver microsomes and mitochondria. The cytochrome P450 content, NADPH-cytochrome c reductase, aminopyrine N-demethylase, and aniline hydroxylase activities in liver microsomes were also increased. PSL significantly increased serum ALT levels, and decreased the liver mitochondrial glutathione content. At the same time, other enzymes activities were all increased. When mice were treated with ASP 2.0 g.kg-1, the PSL-induced changes on cytochrome P450 enzymes, glutathione S-transferase, and GSH content were restored.</p><p><b>CONCLUSION</b>ASP can modulate the activities of drug metabolism enzymes.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Polissacarídeos
/
Microssomos Hepáticos
/
Mitocôndrias Hepáticas
/
Prednisolona
/
Anilina Hidroxilase
/
Química
/
NADPH-Ferri-Hemoproteína Redutase
/
Angelica sinensis
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2003
Tipo de documento:
Artigo
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