Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 135-138, 2003.
Article
em Zh
| WPRIM
| ID: wpr-266801
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To find new active constituents from Rhizome of Cimicifuga foetida.</p><p><b>METHOD</b>Various column chromatographic techniques were employed for isolation and purification. The structures were elucidated on the basis of spectral and chemical evidences.</p><p><b>RESULT</b>Four triterpenoid compounds were isolated and identified as 7,8-didehydro-27-deoxyactein(1), 24-O-acetylshengmanol-3-O-beta-D-xyl (23R, 24R)[2], cimigenol(3), cimigenol-3-O-beta-D-xyl(4).</p><p><b>CONCLUSION</b>Compound 1 is a new compound, 2-4 were obtained from this medicinal material for the first time. The antiosteoporosis activity screening in vitro(by the method of SRB) indicates that Compounds 1, 2 and 4 can promote the proliferation for rat Osteoblastoma cell line (UMR106) at the concentration of 10(-9) kg.L-1.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Plantas Medicinais
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Triterpenos
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Neoplasias Ósseas
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Estrutura Molecular
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Divisão Celular
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Química
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Osteoblastoma
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Rizoma
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2003
Tipo de documento:
Article