Study on optimization method of dynamic extraction process / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To establish a new optimized extraction process based on dynamic changes in extract concentration during the extraction process.</p><p><b>METHOD</b>Sanqi was taken as an example to compare the concentration of marker components, total solids yield and similarity evaluation of the fingerprint images of extracts by orthogonal design optimization process and dynamic optimization process to assess the feasibility of dynamic process optimization method.</p><p><b>RESULT</b>The concentration of marker components and total solids yield vary less than 5%, with a 100% of similarity in fingerprints, indicating basic coincidence between extracts by the two optimized processes. The dynamic process optimization process could save 79% of the extraction time.</p><p><b>CONCLUSION</b>In the extraction time, the dynamic optimization process is superior to the orthogonal design optimization process in that it can significantly reduce the extraction time and lower production costs.</p>