Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1311-1314, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-267026
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine (TMP) in rats.</p><p><b>METHOD</b>Thirty two Sprague-Dawley rats were randomly divided into 4 groups the TMP (30 mg x kg(-1)) group, the TMP+FA (30 mg x kg(-1) + 50 mg x kg(-1)) group, the TMP+TET (30 mg x kg(-1) mg x kg(-1)) group and the TMP+FA+TET (30 mg x kg(-1) + 50 mg x kg(-1) + 20 mg x kg(-1)) group. After the oral administration, their blood samples were collected to detect plasmas concentrations by HPLC method and to calculate pharmacokinetic parameters DAS 2.0 program.</p><p><b>RESULT</b>In compatibility with FA, AUC(0-t), Cmax and Tmax showed no significant difference with the single administration of TMP, but t(1/2) and MRT,, were obviously longer than the single administration. In compatibility with TET and FA + TET, AUC (0-t), Cmax and Tmax showed significant increase than the single administration of TMP, whereas t(1/2) and MRT0, did not notably vary from the single administration.</p><p><b>CONCLUSION</b>FA can prolong TMP's action time in rats, and TET can accelerate TMP's absorption in rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pirazinas
/
Farmacocinética
/
Distribuição Aleatória
/
Cromatografia Líquida de Alta Pressão
/
Ratos Sprague-Dawley
/
Ácidos Cumáricos
/
Diterpenos
/
Interações Medicamentosas
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2012
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS