Non-alkaloid chemical constituents from Coptis chinensis / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To separate and identify chemical constituents from Coptis chinensis.</p><p><b>METHOD</b>The compounds were separated and purified by various chromatographic techniques. Their structures were identified on the basis of their physicochemical properties using spectral techniques such as NMR and MS.</p><p><b>RESULT</b>Thirteen compounds were separated from ethanol extracts of C. chinensis, including seven lignans, three simple phenylpropanoids, two flavones and one phenolic acid, and identified as erythro-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (1), threo-guaiacylglycerol-8-O-4'-(coniferyl alcohol) ether (2), (+)-pinoresinol (3), (+)-medioresinol (4), (+)-lariciresinol (5), (+)-5'-methoxylariciresinol (6), (+)-isolariciresinol (7), chlorogenic acid (8), ferulic acid (9), Z-octadecyl caffeate (10), rhamnetin (11), wogonin (12), and vanillic acid (13).</p><p><b>CONCLUSION</b>Compounds 1, 2, 4, 6, 10-13 were separated from the genus Coptis for the first time.</p>