Your browser doesn't support javascript.
loading
Effect of Bushenhuoxue Yin on cerebral levels of nitric oxide, tumor necrosis factor-α and interferon-γ in a mouse model of Parkinson disease / 南方医科大学学报
Journal of Southern Medical University ; (12): 90-92, 2011.
Artigo em Chinês | WPRIM | ID: wpr-267665
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Bushenhuoxue Yin (BSHXY), a compound traditional Chinese herbal medicine, on nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) levels in the brain of a mouse model of Parkinson disease (PD).</p><p><b>METHODS</b>Forty-five C57BL/6 mice were randomized into MPTP-induced PD model group, BSHXY treatment group and normal control group. The contents of NO and the two cytokines in the brain tissue of the mice were determined by spectroscopy and enzyme-linked immunosorbent assay, respectively.</p><p><b>RESULTS</b>The concentration of NO in the brain tissue of the PD model group was 5.93 ∓ 0.79 µmol/g.protein, significantly higher than that in BSHXY group (P<0.01) and normal control group (P<0.01). The levels of TNF-α and IFN-γ in the PD model group were 0.36 ∓ 0.11 ng/L and 0.83 ∓ 0.25 ng/L, respectively, also higher than those in the other two groups (P<0.01 or 0.001). But BSHXY group and the normal control group showed no significant differences in the levels of NO, TNF-α and IFN-γ (P>0.05).</p><p><b>CONCLUSION</b>The therapeutic effect of BSHXY on PD is partially attributed to decreased content of NO, TNF-α and IFN-γ in the brain.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doença de Parkinson / Farmacologia / Encéfalo / Medicamentos de Ervas Chinesas / Distribuição Aleatória / Interferon gama / Fator de Necrose Tumoral alfa / Usos Terapêuticos / Modelos Animais de Doenças / Tratamento Farmacológico Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2011 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doença de Parkinson / Farmacologia / Encéfalo / Medicamentos de Ervas Chinesas / Distribuição Aleatória / Interferon gama / Fator de Necrose Tumoral alfa / Usos Terapêuticos / Modelos Animais de Doenças / Tratamento Farmacológico Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2011 Tipo de documento: Artigo