hTERT single nucleotide polymorphism is associated with increased risks of hepatocellular carcinoma and tumor metastasis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 49-52, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-267675
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of hTERT single nucleotide polymorphisms on the development and metastasis of hepatocellular carcinoma.</p><p><b>METHODS</b>A total of 290 male patients were divided into hepatitis-induced primary hepatocellular carcinoma (HCC) group (n%162), metastatic HCC group (n%22), and control group (n%106). hTERT gene was amplified and hTERT single nucleotide polymorphisms (SNPs) were tested in these subjects.</p><p><b>RESULTS</b>Significant differences were found in rs2853690 and rs10069690 distribution, but the difference in rs6554743 remained uncertain. The C and T alleles of rs10069690 and rs6554743 showed significant differences between the 3 groups; the carriers of non-T allele of rs10069690 had higher frequencies in both primary and metastatic HCC groups.</p><p><b>CONCLUSION</b>Some of the polymorphisms of hTERT may increase the risks of development and metastasis of hepatocellular carcinoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fatores de Risco
/
Carcinoma Hepatocelular
/
Telomerase
/
Polimorfismo de Nucleotídeo Único
/
Genética
/
Neoplasias Hepáticas
/
Metástase Neoplásica
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2011
Tipo de documento:
Artigo
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