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Differential expression of hsa-miR-126 and hsa-miR-518b in esophageal squamous carcinoma / 南方医科大学学报
Journal of Southern Medical University ; (12): 23-27, 2011.
Artigo em Chinês | WPRIM | ID: wpr-267680
ABSTRACT
<p><b>OBJECTIVE</b>To identify the differentially expressed microRNAs (miRNAs) between esophageal squamous carcinoma (ESC) and adjacent non-tumorous tissue (NT).</p><p><b>METHODS</b>The expression levels of the miRNAs were detected in 3 fresh ESC and NT samples by hybridization with miRNAs microarray chip. Real-time quantitative RT-PCR was performed to confirm the results of the microarray analysis. The expressions of hsa-miR-126 and hsa-miR-518b in ESC were validated by real-time quantitative RT-PCR in another independent 15 matched samples.</p><p><b>RESULTS</b>A total of 11 miRNAs exhibited differential expressions in ESC samples as compared to their expressions in the NT samples, including a 1 up-regulated miRNA and 10 down-regulated miRNAs. Compared with normal esophageal samples, the ESC tissues showed up-regulated hsa-miR-126 and down-regulated hsa-miR-518b expression.</p><p><b>CONCLUSION</b>hsa-miR-126 and hsa-miR-518b are differentially expressed in ESC, and they might play important roles in the carcinogenesis and progression of ESC.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Neoplasias Esofágicas / Células Tumorais Cultivadas / Carcinoma de Células Escamosas / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Perfilação da Expressão Gênica / MicroRNAs / Genética / Metabolismo Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Neoplasias Esofágicas / Células Tumorais Cultivadas / Carcinoma de Células Escamosas / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Perfilação da Expressão Gênica / MicroRNAs / Genética / Metabolismo Limite: Humanos Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2011 Tipo de documento: Artigo