Effect of electroacupuncture on pain threshold and spinal NR2B subunit expression in a rat model of neuropathic pain / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2702-2704, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-267702
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of electroacupuncture (EA) on pain threshold and spinal NR2B subunit expression in a rat model of neuropathic pain due to chronic compression injury (CCI) of the sciatic nerve and explore the analgesic mechanism of EA.</p><p><b>METHODS</b>Male SD rats weighing 200-280 g were randomly divided into 4 groups (n=10), namely the sham-operated group, CCI group, EA+CCI group, and sham EA+CCI group. All the rats underwent tests of the mechanical withdrawal threshold and thermal threshold. On day 13 after the surgery, all the rats were decapitated to collect the L4-6 segments of the spinal cord to examine NR2B expression using Western blotting.</p><p><b>RESULTS</b>The postoperative mechanical withdrawal threshold and thermal threshold were significantly lowered in CCI, EA+CCI and sham EA+CCI groups as compared to those before the surgery (P<0.05). EA obviously alleviated the hypersensitivity in the rats with CCI and inhibited spinal NR2B expressions (P<0.05). No significant differences were found in the mechanical withdrawal threshold, thermal threshold or spinal NR2B subunit expression between CCI group and sham EA+CCI group (P>0.05).</p><p><b>CONCLUSION</b>EA may alleviate neuropathic hypersensitivity partially by inhibiting NR2B expression in the spinal cord of rats with neuropathic pain resulting from CCI of the sciatic nerve.</p>
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Medula Espinal
/
Terapêutica
/
Eletroacupuntura
/
Ratos Sprague-Dawley
/
Limiar da Dor
/
Receptores de N-Metil-D-Aspartato
/
Metabolismo
/
Neuralgia
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
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