Expression of c-myb in reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of c-myb in reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma.</p><p><b>METHODS</b>The expression levels of c-myb in the esophageal mucosa tissue of patients with reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma were detected by real-time fluorescent quantitative RT-PCR.</p><p><b>RESULTS</b>The expression levels of c-myb mRNA in Barrett esophagus and esophageal adenocarcinoma tissues was significantly higher than that in normal and reflux esophagitis esophageal tissue (P<0.05 or 0.01), and increased progressively with the development of reflux esophagitis into Barrett esophagus and esophageal adenocarcinoma.</p><p><b>CONCLUSIONS</b>The expression level of c-myb mRNA is closely related with the development of Barrett esophagus and esophageal adenocarcinoma, and may be used as a valuable index for monitoring the early onset and intervention of Barrett esophagus and esophageal adenocarcinoma.</p>