Application of NOD/SCID mice in research of experimental hematology - review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 964-968, 2008.
Article
em Zh
| WPRIM
| ID: wpr-267848
Biblioteca responsável:
WPRO
ABSTRACT
NOD/SCID (non-obese diabetic/severe combined immunodeficient) mice are immune deficient mice which are made by backcross of severe combined immunodeficient mice with non-obese diabetic mice strains. NOD/SCID mice are both innate immune deficiencies and lack of T and B lymphocytes. Various tumor cells can be implanted in this kind of mice, the rejection and graft-versus-host disease (GVHD) occur fewer. Therefore, NOD/SCID mice gradually become a useful tool for the study on Experimental Hematology. This paper comprehensively reviews the biological characteristics of NOD/SCID mice, the establishment of human leukemia model, stem cell transplantation, drug research, deficiency and improvement of NOD/SCID mice in application for study.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pesquisa
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Leucemia
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Camundongos SCID
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Camundongos Endogâmicos NOD
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Modelos Animais
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Modelos Animais de Doenças
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Hematologia
/
Métodos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2008
Tipo de documento:
Article