Mechanisms underlying the expression regulation of HOXB4 transcription in hematopoietic stem cells - review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 960-963, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-267849
ABSTRACT
As a member of the hox gene family, hoxB4 gene encodes a class of DNA-dependent homeobox domain nucleoprotein, which is a specific transcription factor, playing an important role in regulating the balance between self-renewal and differentiation of hematopoietic stem cells (HSCs). Therefore, it is important to understand the mechanisms involved in regulating expression of hoxB4 in the HSC. Previous studies have suggested that some hoxB4 upstream regulatory factors, such as USF-1 (upstream activating factor -1), USF-2 (upstream activating factor -2) and NF-Y complex, as well as hematopoietic cytokines, such as platelet growth factor (TPO) and Wnt3a protein, play important regulatory roles in the expression of hoxB4 in hematopoietic stem cells. In this review the structure and biological characteristics of hoxB4, mechanisms involved in regulating expression of hoxB4 in the HSC are summarized.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Fatores de Transcrição
/
Células-Tronco Hematopoéticas
/
Regulação da Expressão Gênica
/
Genes Homeobox
/
Proteínas de Homeodomínio
/
Fator de Ligação a CCAAT
/
Proteínas Wnt
/
Fatores Estimuladores Upstream
/
Proteína Wnt3
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2008
Tipo de documento:
Artigo
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