Mechanism of ligustrazine promoting hematopoietic reconstitution in syngenic bone marrow transplanted mice / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 852-854, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-267874
ABSTRACT
The objective of this study was to investigate the effect of ligustrazine on the expression of stem cell factor mRNA (SCF) in bone marrow tissue and explore the mechanism of hematopoietic reconstitution after bone marrow transplantation (BMT). The colony forming unit of spleen (CFU-S) were counted, the survival rate at days 7, 14 and 21 after BMT were measured, as well as the expression level of SCF mRNA was detected by RT-PCR. The results showed that in ligustrazine group CFU-S counts on day 10 and survival rate, expression level of SCF mRNA on day 7, 14 and 21 after BMT were higher than that in the control group (p < 0.01 or p < 0.05). In conclusion, ligustrazine promotes the recovery of hematopoietic cells in bone marrow, enhances the repair of bone marrow microvessels, and then improves bone marrow microenvironment and promotes hematopoietic reconstitution.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Pirazinas
/
Transplante Isogênico
/
RNA Mensageiro
/
Transplante de Medula Óssea
/
Fator de Células-Tronco
/
Genética
/
Hematopoese
/
Metabolismo
/
Camundongos Endogâmicos BALB C
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2008
Tipo de documento:
Artigo
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