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Nucleotide Excision Repair Gene ERCC2 and ERCC5 Variants Increase Risk of Uterine Cervical Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 708-714, 2016.
Artigo em Inglês | WPRIM | ID: wpr-26790
ABSTRACT

PURPOSE:

Defects in the DNA damage repair process can cause genomic instability and play an important role in cervical carcinogenesis. The purpose of this study was to analyze the association of 29 candidate single nucleotide polymorphisms (SNPs) in genes in the DNA repair pathway, TP53, and TP53BP1 with the risk of cervical cancer. MATERIALS AND

METHODS:

Twenty-nine SNPs in four genes in the DNA repair pathway (ERCC2, ERCC5, NBS1, and XRCC1), TP53, and TP53BP1 were genotyped for 478 cervical cancer patients and 922 healthy control subjects, and their effects on cervical carcinogenesis were analyzed.

RESULTS:

The most significant association was found for rs17655 in ERCC5, with an age-adjusted p-value < 0.0001, for which a strong additive effect of the risk allele C was observed (odds ratio, 2.01 for CC to GG). On the other hand, another significant polymorphism rs454421 in ERCC2 showed a dominant effect (odds ratio, 1.68 for GA+AA to GG) with an age-adjusted p-value of 0.0009. The association of these polymorphisms remained significant regardless of the age of onset. The significant result for rs17655 was also consistent for subgroups of patients defined by histology and human papillomavirus (HPV) types. However, for rs454421, the association was observed only in patients with squamous cell carcinoma and non-HPV 18 type.

CONCLUSION:

The results of this study show a novel association of cervical cancer and the genes involved in the nucleotide excision pathway in the Korean population.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dano ao DNA / Carcinoma de Células Escamosas / Neoplasias do Colo do Útero / Idade de Início / Polimorfismo de Nucleotídeo Único / Instabilidade Genômica / Reparo do DNA / Alelos / Carcinogênese / Mãos Tipo de estudo: Estudo de etiologia Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dano ao DNA / Carcinoma de Células Escamosas / Neoplasias do Colo do Útero / Idade de Início / Polimorfismo de Nucleotídeo Único / Instabilidade Genômica / Reparo do DNA / Alelos / Carcinogênese / Mãos Tipo de estudo: Estudo de etiologia Limite: Humanos Idioma: Inglês Revista: Cancer Research and Treatment Ano de publicação: 2016 Tipo de documento: Artigo