Relationship between mitochondrial DNA and myelodysplastic syndromes - review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 712-716, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-267905
ABSTRACT
Mitochondria is the main place of biological oxidation and energy transform. Mitochondrial DNA encodes the complex of respiratory chain in mitochondria and its mutation can cause a series of human disease. Mitochondrial DNA mutation which observed in myelodysplastic syndrome (MDS) patients cause the MDS by the mechanism of iron metabolism disorder, gene instability and hemopoietic progenitor cell apoptosis. In this review the characteristics of mitochondrial DNA structure, the mitochondrial DNA mutation and the possible mechanism of mitochondrial DNA mutation in pathogenesis of MDS were summarized.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndromes Mielodisplásicas
/
DNA Mitocondrial
/
Mutação Puntual
/
Genética
/
Anemia Sideroblástica
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2008
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS