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Phase IIa clinical trail of hemocoagulase acutus for injection / 南方医科大学学报
Journal of Southern Medical University ; (12): 644-646, 2007.
Artigo em Chinês | WPRIM | ID: wpr-268058
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of hemocoagulase acutus for injection and determine its curative dose.</p><p><b>METHODS</b>Forty-five patients on abdominal surgeries were randomly allocated into 2 study groups and 1 control group. Thirty minutes before the operation, the patients in the study groups received intravenous hemocoagulase acutus at 1 U and 2 U, respectively, and control group had no treatment. The hemostatic time, hemorrhagic volume, and hemoagglutination were observed in all the groups.</p><p><b>RESULTS</b>The average hemorrhagic volume and hemorrhagic volume per square were significantly lower in the two study groups than in the control group (P<0.05), and the average hemorrhagic volume per square were significantly lower in study group 2 U than in the 1 U group (P<0.05). No significant differences were found in adverse effects between the 3 groups.</p><p><b>CONCLUSION</b>Hemocoagulase acutus for injection has good hemostatic effect for controlling capillary hemorrhage at the abdominal incisions and can be safely used in the surgical patients.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cirurgia Geral / Coagulação Sanguínea / Hemostáticos / Batroxobina / Perda Sanguínea Cirúrgica / Resultado do Tratamento / Agkistrodon / Usos Terapêuticos / Abdome / Hemostasia Cirúrgica Limite: Animais / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cirurgia Geral / Coagulação Sanguínea / Hemostáticos / Batroxobina / Perda Sanguínea Cirúrgica / Resultado do Tratamento / Agkistrodon / Usos Terapêuticos / Abdome / Hemostasia Cirúrgica Limite: Animais / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2007 Tipo de documento: Artigo