Expression of hypoxia-inducible factor-1alpha in endometriosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 538-540, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-268082
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis.</p><p><b>METHODS</b>Immunohistochemistry was performed to examine the expression of HIF-1alpha in 20 normal endometrium, 20 ectopic endometrium and 68 eutopic endometrium specimens from 68 endometriosis patients, and the results were analyzed statistically.</p><p><b>RESULTS</b>The expression of HIF-1alpha was significantly increased in ectopic endometrium than in normal endometrium (P<0.01), and the expression did not undergo changes with the normal menstrual cycle in the three types of endometrium.</p><p><b>CONCLUSION</b>HIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Endometriose
/
Endométrio
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Genética
/
Ciclo Menstrual
/
Metabolismo
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo
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