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Changes of CD4+CD28- T cell and CD4+CD25+ regulatory T cell subsets in patients with coronary heart disease / 南方医科大学学报
Journal of Southern Medical University ; (12): 474-476, 2007.
Artigo em Chinês | WPRIM | ID: wpr-268101
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes of CD4(+)CD28(-) T cell and CD4(+)CD25(+) regulatory T cell (Treg) subsets in patients with coronary artery disease (CAD).</p><p><b>METHODS</b>Twenty-eight patients with angiographically established CAD were recruited in this study, including 16 with unstable angina (UA group) and 12 with stable angina (SA group). Eleven patients with chest pain syndrome served as the control group. The proportions of peripheral CD4(+)CD28(-) T cells and CD4(+)CD25(+) Treg subsets were determined with fluorescence-activated cell sorting (FACS).</p><p><b>RESULTS</b>The proportions of CD4(+)CD25(+) Treg were significantly lower in UA group (6.55-/+2.45%) than in SA (14.01-/+4.92%) and control groups (13.55-/+3.87%). The proportions of CD4(+)CD28(-) T cells were significantly higher in UA group (10.55-/+4.76%) than in SA (2.64-/+1.33%) and control (2.75-/+1.55%) groups.</p><p><b>CONCLUSION</b>Alterations of circulating T-lymphocyte subsets occur in patients with UA. The changes of Treg and CD4(+)CD28(-) T cells may lead to breakdown of peripheral autoimmune tolerance and play an important role in the development and progression of CHD.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Linfócitos T CD4-Positivos / Estudos de Casos e Controles / Subpopulações de Linfócitos T / Linfócitos T Reguladores / Antígenos CD28 / Doença das Coronárias / Alergia e Imunologia / Subunidade alfa de Receptor de Interleucina-2 / Angina Instável Tipo de estudo: Estudo observacional Limite: Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Linfócitos T CD4-Positivos / Estudos de Casos e Controles / Subpopulações de Linfócitos T / Linfócitos T Reguladores / Antígenos CD28 / Doença das Coronárias / Alergia e Imunologia / Subunidade alfa de Receptor de Interleucina-2 / Angina Instável Tipo de estudo: Estudo observacional Limite: Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2007 Tipo de documento: Artigo