Progress in the design of selective ATP-competitive kinase inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1232-1236, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-268199
ABSTRACT
Kinases play crucial roles in the life of cell. Their functional abnormity usually leads to many human major diseases including tumors. The prospecting of ATP-competitive small-molecule kinase inhibitors targeting kinases of therapeutic interest has become the focus of researches. Due to the high conservation of the catalytic domain of kinases, the selectivity of kinase inhibitors is poor in general. However, along with the development of structural biology and computer-aided drug design, great progress in the research of selective, ATP-competitive kinase inhibitors has been achieved in recent years. In this account, the review has been made on the development of the design of selective kinase inhibitors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Ligação Proteica
/
Ligação Competitiva
/
Desenho de Fármacos
/
Estrutura Molecular
/
Trifosfato de Adenosina
/
Química
/
Inibidores de Proteínas Quinases
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2007
Tipo de documento:
Artigo
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