Potential role of microRNAs in human diseases and the exploration on design of small molecule agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1115-1121, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-268220
ABSTRACT
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene modulation by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mRNAs. miRNA alterations are involved in the initiation and progression of human diseases. miRNA-expression profiling of human diseases has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. Recent evidence has suggested miRNAs as viable therapeutic targets for a wide range of human diseases. Several approaches were performed, the experimental examination of these techniques and the resultant findings not only indicate feasibility of interfering miRNA action in a gene-specific fashion but also may provide a new research tool for studying function of miRNAs. The new approaches also have the potential of becoming alternative gene therapy strategies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
RNA Mensageiro
/
Desenho de Fármacos
/
Terapia Genética
/
Regulação da Expressão Gênica
/
Perfilação da Expressão Gênica
/
Inativação Gênica
/
MicroRNAs
/
Genética
/
Cardiopatias
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2007
Tipo de documento:
Artigo
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