Alteration of interleukin-17/interferon-γ double positive cells in mice with Coxsackie virus induced myocarditis / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 1135-1139, 2011.
Article
em Zh
| WPRIM
| ID: wpr-268244
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the alteration of interleukin-17 and interferon-γ double positive cells (IL-17(+)/IFN-γ(+) cells) in mice with coxsackie virus B3 (CVB3) induced acute viral myocarditis (VMC).</p><p><b>METHODS</b>VMC was induced in male Balb/c mice by peritoneal injection of CVB3. Control mice received PBS injection. At 0, 1, 2, 3, 4 and 6 weeks after injection, pathological scores were determined on hematoxylin-eosin stained heart sections and flow cytometric analysis was performed to evaluate the percent of IL-17(+)/IFN-γ(+) cells among CD4(+) T cells.</p><p><b>RESULTS</b>Compared to control mice, the pathological scores of VMC mice were higher on CVB3 infection week 1 (1.8 ± 0.5), peaked on week 2 (2.8 ± 0.5) and declined thereafter. However, the proportion of IL-17(+)/IFN-γ(+) cells remained steadily at a low level throughout the observation period and was similar between VMC and control mice.</p><p><b>CONCLUSIONS</b>Our data shows that IL-17(+)/IFN-γ(+) cells might not be involved in the inflammation process of CVB3 induced VMC mice model.</p>
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Virologia
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Interferon gama
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Enterovirus
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Interleucina-17
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Infecções por Coxsackievirus
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Modelos Animais de Doenças
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Alergia e Imunologia
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Células Th17
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Metabolismo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2011
Tipo de documento:
Article