Intima-media thickness and left ventricle remodeling in patients with prehypertension and impaired glucose tolerance / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 1105-1109, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-268249
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the intima-media thickness and cardiac remodeling in patients with prehypertension and impaired glucose tolerance.</p><p><b>METHOD</b>Three-hundred patients were divided into four groups normal control (NC, n = 61), prehypertension (PH, n = 83), impaired glucose tolerance (IGT, n = 91), prehypertension and impaired glucose tolerance (PH + IGT, n = 65). Intima-media thickness (IMT) was measured by doppler ultrasonography. Left ventricle mess (LVMI), midwall fractional shortening (mFS), peakE/peakA (E/A) were measured by echocardiography.</p><p><b>RESULTS</b>(1) IMT was significantly increased in PH, IGT and PH + IGT groups than in NC group [(0.7 ± 0.1) mm, (0.7 ± 0.1) mm and (1.0 ± 0.1) mm vs.(0.6 ± 0.1) mm, all P < 0.01], which was significantly high in PH + IGT group than in PH or IGT group. Regression analysis demonstrated that high-sensitivity C-reactive protein (hs-CRP), 2-hour postprandial blood glucose (2hPBG), systolic pressure (SBP), diastolic blood pressure (DBP) were independent predictors to increased IMT. (2) LVMI was higher in PH and PH + IGT groups than in NC group [(97.0 ± 3.3) g/m(2), (97.1 ± 2.8) g/m(2) vs.(87.0 ± 2.0) g/m(2), (87.9 ± 1.5) g/m(2), all P < 0.01], and positively related with SBP, DBP. (3) mFS was lower in PH and PH + IGT groups [(14.0 ± 0.8)%, (14.0 ± 0.8)% vs. (18.3 ± 1.0)%, (18.2 ± 0.5)%, P < 0.01], negatively related with SBP and DBP. E/A was similar among groups and lower E/A was associated with higher SBP.</p><p><b>CONCLUSION</b>Vascular and left ventricular structure remodeling and systolic dysfunction could be detected in prehypertension patients. Impaired glucose tolerance could enhance vascular remodeling in prehypertension patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Estudos de Casos e Controles
/
Intolerância à Glucose
/
Remodelação Ventricular
/
Pré-Hipertensão
/
Espessura Intima-Media Carotídea
/
Metabolismo
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Cardiology
Ano de publicação:
2011
Tipo de documento:
Artigo
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