Recent progress in the study of HIV-1 transcription factor NF-kappaB and its inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1007-1012, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-268538
ABSTRACT
Human immunodeficiency virus type 1 (HIV-1) transcription is a crucial step in the viral replication cycle, which is considered to be a potential target for inhibition of HIV-1 replication. Among the factors involved in this step, the cellular protein nuclear factor NF-kappaB is the most powerful inducer of HIV-1 transcription. HIV-1 transcription is initiated by the binding of NF-kappaB to the enhancer region in the long terminal repeat (LTR) of HIV-1. Several compounds suppress HIV-1 transcription through the inhibition of NF-kappaB activation. The mechanisms of NF-kappaB in the transcription of HIV-1 and progress of the current inhibitors of NF-kappaB are reviewed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Transcrição Gênica
/
Replicação Viral
/
Repetição Terminal Longa de HIV
/
NF-kappa B
/
HIV-1
/
Fármacos Anti-HIV
/
Proteínas I-kappa B
/
Quinase I-kappa B
/
Inibidor de NF-kappaB alfa
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2007
Tipo de documento:
Artigo
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