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Determination of mosapride in human plasma by high performance liquid chromatography tandem mass spectrometry / 药学学报
Acta Pharmaceutica Sinica ; (12): 882-885, 2007.
Artigo em Chinês | WPRIM | ID: wpr-268560
ABSTRACT
To develop a sensitive and specific high performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method for the determination of mosapride in human plasma, mosapride and internal standard tamsulosin were extracted from plasma with liquid-liquid extraction, then separated on a Waters ACQUITY UPLC BEH C18 column (50 mm x 2.1 mm, 1.7 microm ID) with gradient elution at flow-rate of 0.25 mL x min(-1). The mobile phase was water (containing 0.3% formic acid) and acetonitrile under gradient conditions. Electrospray ionization (ESI) source was applied and operated in the positive ion mode. Multiple reaction monitoring (MRM) mode with the transitions of m/z 422 --> m/z 198 and m/z 409 --> m/z 228 were used to quantify mosapride and the internal standard, respectively. The linear calibration curve was obtained in the concentration range of 0.17 - 68.00 ng x mL(-1). The lower limit of quantification was 0.17 ng x mL(-1). The inter- and intra-day precision (RSD) was less than 13%, and the accuracy (RE) was within +/- 6.3% calculated from QC samples. The method was used to determine the concentration of mosapride in plasma after a single oral dose of 5 mg mosapride citrate to 20 healthy male Chinese volunteers. The method has been proved to be selective, sensitive, rapid and suitable for pharmacokinetic study of mosapride.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Benzamidas / Sangue / Fármacos Gastrointestinais / Farmacocinética / Morfolinas / Administração Oral / Cromatografia Líquida de Alta Pressão / Sensibilidade e Especificidade / Agonistas do Receptor de Serotonina / Área Sob a Curva Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Limite: Humanos / Masculino Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Benzamidas / Sangue / Fármacos Gastrointestinais / Farmacocinética / Morfolinas / Administração Oral / Cromatografia Líquida de Alta Pressão / Sensibilidade e Especificidade / Agonistas do Receptor de Serotonina / Área Sob a Curva Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Limite: Humanos / Masculino Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2007 Tipo de documento: Artigo