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Relationship between cellular immune function during conditioning and graft rejection in patients with beta-thalassemia major / 南方医科大学学报
Journal of Southern Medical University ; (12): 1375-1377, 2009.
Artigo em Chinês | WPRIM | ID: wpr-268756
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the relationship between cell-mediated immune function during conditioning and graft rejection in patients with beta-thalassemia major.</p><p><b>METHODS</b>Allogeneic hematopoietic stem cell transplantation was performed in 25 children with beta-thalassemia major and 11 with acute leukemia group. The percentages of T lymphocytes and natural killer (NK) cells in peripheral blood of these patients were detected with dual color immunofluorescence on day -10 (before conditioning) and day -5 (after conditioning), and the relationship between the cellular immune function and graft rejection was analyzed.</p><p><b>RESULTS</b>All the patients with acute leukemia showed engraftment. The rate of graft rejection was 34.8% in the patients with beta-thalassemia major. Compared with the leukemic patients, the patients with beta-thalassemia showed significantly increased percentage of CD3(+)CD8(+) T lymphocytes before and after the conditioning (P<0.05). The percentage of CD3(-)CD56(+) NK cells increased significantly in patients with beta-thalassemia major after the conditioning (P<0.05), but decreased markedly after conditioning in the leukemic patients (P<0.05). In patients with beta-thalassemia major and graft rejection, the CD3(-)CD56(+) cell phenotype was predominant after conditioning but remained unchanged in those with engraftment.</p><p><b>CONCLUSION</b>CD3(-)CD56(+) NK cells are probably associated with graft rejection in patients with beta-thalassemia major, and may serve as an index for predicting graft rejection following allogeneic hematopoietic stem cell transplantation.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cirurgia Geral / Células Matadoras Naturais / Estudos de Casos e Controles / Talassemia beta / Contagem de Linfócitos / Transplante de Células-Tronco Hematopoéticas / Biologia Celular / Alergia e Imunologia / Rejeição de Enxerto / Doença Enxerto-Hospedeiro Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adolescente / Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Cirurgia Geral / Células Matadoras Naturais / Estudos de Casos e Controles / Talassemia beta / Contagem de Linfócitos / Transplante de Células-Tronco Hematopoéticas / Biologia Celular / Alergia e Imunologia / Rejeição de Enxerto / Doença Enxerto-Hospedeiro Tipo de estudo: Estudo observacional / Fatores de risco Limite: Adolescente / Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2009 Tipo de documento: Artigo