Effect of local treatment with cooling and spray film on early edema of superficial II degree scald burns in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 804-806, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-268836
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-inflammatory effect of early local treatment with cooling and spray film on scald burn injury in rats.</p><p><b>METHOD</b>Seventy-five Wistar rats were randomly divided into 5 groups including the sham-scalded group, untreated scald group, cooling group, spray film group, and cooling plus spray film group with corresponding treatments. After gross observation of the wounds, the tissues at the wounds were sampled at different time points after the injury to determine the total water content (wet dry weight ratio) and prostaglandin E(2) (PGE(2)) levels using radioimmunoassay (RIA).</p><p><b>RESULTS</b>Treatment with cooling and spray film significantly alleviated the swelling and effusion of the scald burns. At each of the time points, the water content and PGE(2) levels in the cooling group, spray film group and cooling plus spray film group were all lower than those in untreated scald group (P<0.01), but all higher than those in the sham-scalded group (P<0.01). The water content and PGE(2) levels were the lowest in cooling plus spray film group, and a significant correlation was noted between the water content and PGE(2) levels in the untreated scald group, cooling group, spray film group and cooling plus spray film group (P<0.01).</p><p><b>CONCLUSIONS</b>Local treatment with cooling and spray film can alleviate the edema of superficial II degree scald burns in rats probably by reducing the levels of the inflammatory cytokines in the local tissues.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Terapêutica
/
Fatores de Tempo
/
Queimaduras
/
Dinoprostona
/
Ratos Wistar
/
Crioterapia
/
Edema
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo
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