Vitamin D receptor genetic polymorphisms and tuberculosis among Chinese Han ethnic group / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 920-925, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-269326
ABSTRACT
<p><b>BACKGROUND</b>In epidemiological studies, tuberculosis (TB) appears intimately with vitamin D insufficiency whereas its relationship with vitamin D receptor (VDR) polymorphism caused by radical difference remains unspecified. This study aimed to investigate the relationship between vitamin D genetic polymorphism and tuberculosis in Han ethnic group.</p><p><b>METHODS</b>Meta-analysis was adopted in the synthetic quantitative analysis of documents home and abroad on the relationship between vitamin D genetic polymorphisms and tuberculosis, which were openly published during June 2000 to January 2010. Random effect model and fixed effect model analyses were used to calculate the incorporated odds ratio (OR) based on the heterogeneity test data.</p><p><b>RESULTS</b>A total of 6 eligible studies were included in this analysis. The FokI-ff genotype showed a significant marginal association (Fixed effect model OR 1.91, 95%CI 1.44-2.52; Random effect model OR 1.91, 95%CI 0.94-3.88), yet TaqI polymorphisms was not significantly related to TB.</p><p><b>CONCLUSION</b>The interaction between FoKI genotype polymorphism and TB observed demonstrates that vitamin D deficiency might exist as a risk factor during the development of TB in Han ethnic group and more evidences needed to validate the conclusion.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Tuberculose
/
Estudos de Casos e Controles
/
Epidemiologia
/
Receptores de Calcitriol
/
Predisposição Genética para Doença
/
Povo Asiático
/
Genética
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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