Diagnostic values of neopterin and S100b for central nervous system infections in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 380-383, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-269468
ABSTRACT
<p><b>OBJECTIVE</b>To study the diagnostic values of cerebrospinal concentrations of neopterin (NPT) and S100b for central nervous system infections in children.</p><p><b>METHODS</b>Enzyme-linked immunosorbent assay was used to determinate the cerebrospinal concentrations of NPT and S100b in children with central nervous system infections and control children. The two groups of children were compared in terms of the two indicators, and the diagnostic values of the two indicators were evaluated by ROC curve analysis.</p><p><b>RESULTS</b>Children with viral encephalitis had significantly increased cerebrospinal concentrations of NPT and S100b compared with the control group and children with purulent meningitis (P<0.01); there was no difference in the cerebrospinal concentration of NPT between children with purulent meningitis and the control group, while the concentration of S100b in the purulent meningitis group was significantly higher than in the control group (P<0.01). According to the ROC curves, S100b was more valuable than NPT in the diagnosis of viral encephalitis; when cerebrospinal concentration was more than 0.384 ng/mL, S100b had a sensitivity of 93.3% and a specificity of 97.9%; a combination of the two indicators had a higher diagnostic value for viral encephalitis, with a sensitivity of 96.7% and a specificity of 97.9%.</p><p><b>CONCLUSIONS</b>Both NPT and S100b have certain values in the diagnosis of central nervous system infections in children, and S100b is better than NPT.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Infecções do Sistema Nervoso Central
/
Líquido Cefalorraquidiano
/
Curva ROC
/
Neopterina
/
Diagnóstico
/
Subunidade beta da Proteína Ligante de Cálcio S100
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2014
Tipo de documento:
Artigo
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