Research progress in mechanisms of drug-induced nephrotoxicity / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 330-334, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-269478
ABSTRACT
Drug-induced nephrotoxicity in children is dependent upon the histological, anatomical and physiological features of their kidneys and the structural and functional characteristics of drugs. The kidney is mainly composed of microvascular network and tubulointerstitial tissue, so drug-induced nephrotoxicity is usually manifested by interstitial nephropathy. The mechanisms of drug-induced nephrotoxicity include cytotoxicity (necrosis or apoptosis), ischemic injury, and immunological injury. Individual drugs cause renal damage by various mechanisms due to differences in chemical structure and pharmacology. This article reviews the main features of nephrotoxicity induced by common antibiotics (cephalosporins, aminoglycosides, vancomycin, carbapenems and amphotericin B), non-steroidal anti-inflammatory drugs, and cyclosporine A.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Ciclosporina
/
Toxicidade
/
Nefropatias
/
Antibacterianos
Limite:
Criança
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2014
Tipo de documento:
Artigo
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