Survey of the evolutionary characteristics of influenza H1N1 hemagglutinin gene HA1 in 2000-2009 / 南方医科大学学报
Journal of Southern Medical University
;
(12): 92-95, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-269619
ABSTRACT
<p><b>OBJECTIVE</b>To study the global evolutionary characteristics of hemagglutinin gene HA1 of influenza H1N1 infecting different species during 2000-2009.</p><p><b>METHODS</b>The target sequences were downloaded from NCBI and analyzed using bioinformatic software to construct the phylogenetic tree.</p><p><b>RESULTS</b>The HA1 amino acid sequences of influenza H1N1 contained four mutated antigenic sites and receptor-binding sites, and the novel influenza virus shared most of the mutated amino acid sites with swine H1N1 influenza virus.</p><p><b>CONCLUSION</b>The HA1 gene of novel influenza virus might originate from the early swine H1N1 influenza virus from North America, and in the evolutionary process, a number of important sites of HA1 gene mutated to result in the outbreak of influenza.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filogenia
/
Virologia
/
Variação Antigênica
/
China
/
Epidemiologia
/
Glicoproteínas de Hemaglutininação de Vírus da Influenza
/
Biologia Computacional
/
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
/
Genes Virais
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS