Selective Proximal Tubule Injury and Progressive Renal Failure due to Ifosfamide and Cisplatin in a Patient with Ovarian Cancer / 대한신장학회지
Korean Journal of Nephrology
;
: 513-517, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-26987
ABSTRACT
Ifosfamide-induced nephrotoxicity is usually manifested in the form of Fanconi syndrome and the combination of cisplatin enhances ifosfamide-induced nephrotoxicity. We here report a case of report specific proximal tubular dysfunction and progressive renal failure after ifosfamide and cisplatin chemotherapy in a 32-year old woman with ovarian cancer. The patient was referred to our department due to severe hypokalemia and elevated serum creatinine. Her renal function was abruptly impaired and serum and urine electrolytes were consistent with Fanconi syndrome. The kidney biopsy revealed atrophy and falling of renal tubular cells, and immunohistochemical staining with aquaporin 1 (AQP1) revealed that injured epithelial cells were proximal tubular cells. This finding suggests that ifosfamide selectively impairs proximal tubule function and combination with cisplatin causes progressive renal failure
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ovarianas
/
Atrofia
/
Biópsia
/
Cisplatino
/
Creatinina
/
Eletrólitos
/
Células Epiteliais
/
Insuficiência Renal
/
Aquaporina 1
/
Síndrome de Fanconi
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Nephrology
Ano de publicação:
2008
Tipo de documento:
Artigo
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