Comparative study on effect of Tripterygium polyglycosides on mucous immune function of rat models of arthritis induced by collagen II and by adjuvant / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 723-726, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-269915
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Tripterygium polyglycosides (TWP) on mucous immune function in rat models of arthritis induced respectively with collagen-II induced arthritis (CIA) & adjuvant arthritis (AA).</p><p><b>METHODS</b>CIA and AA model rats were induced by immunization with collagen II emulsified with complete Freund's adjuvant and complete Freund's adjuvant respectively and treated with TWP. Rats' mucus, systemic immunological indexes (peripheral subsets of T cells), local inflammatory factors (IL-6, TNF-alpha, COX-2,and NF-kappaB, etc. ) were observed.</p><p><b>RESULTS</b>In CIA model group, CD4+ in Peyer's Patch (PP), peripheral CD4+ and CD8+ positive T cells all raised, while in the AA model group, CD4+ lowered and CD8+ raised on PP, with both subsets increased. Effects of TWP on T lymphocyte subsets in PP and blood of the two models were different. High leveled IL-6, TNF-alpha, COX-2 and NF-kappaB expression could be seen in both model groups, and these inflammatory media could be inhibited by TWP.</p><p><b>CONCLUSION</b>There exist similarities and differences between the two models in aspects of mucus immune response and effect of TWP on them.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Artrite Experimental
/
Química
/
Adjuvante de Freund
/
Ratos Sprague-Dawley
/
Tripterygium
/
Colágeno Tipo II
/
Tratamento Farmacológico
/
Alergia e Imunologia
/
Glicosídeos
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS