Mechanism of the effect of Tongluo Recipe against glomerular sclerosis in rats / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1198-1201, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-270176
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Tongluo Recipe on the expression of collagen IV (Col IV), fibronectin (FN), laminin (LN), transforming growth factor-beta1 (TGF-beta1) in rat renal tissues and explore the mechanism underlying these effects in rats with glomerular sclerosis.</p><p><b>METHODS</b>The pathological changes in the renal tissues of rats with glomerular sclerosis were observed microscopically, and the expressions of Col IV, FN, LN, and TGF-beta1 were detected using immunohistochemical staining and image analysis system.</p><p><b>RESULTS</b>Tongluo Recipe significantly decreased the expressions of Col IV, FN, LN and TGF-beta1 in the renal tissue of rats with glomerular sclerosis (P<0.05 or P<0.01) and obviously alleviated the renal pathologies (P<0.01).</p><p><b>CONCLUSION</b>The therapeutic effects of Tongluo Recipe are probably mediated by lowered expressions of Col IV, FN, LN and TGF-beta1.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Medicamentos de Ervas Chinesas
/
Glomerulosclerose Segmentar e Focal
/
Distribuição Aleatória
/
Fibronectinas
/
Resultado do Tratamento
/
Ratos Sprague-Dawley
/
Colágeno Tipo IV
/
Usos Terapêuticos
/
Tratamento Farmacológico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2008
Tipo de documento:
Artigo
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