Immunological activity of Streptomyces polysaccharide in normal and immunosuppressed mice / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1168-1171, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-270184
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the immunological activity of Streptomyces polysaccharide (SMP) on normal and immunosuppressed mice.</p><p><b>METHODS</b>The effect of SMP on the proliferating activity of normal mouse splenocytes was tested in the mixed lymphocyte culture, and the changes of peripheral blood T lymphocytes were evaluated with acid a-naphthyl acetate esterase (ANAE) method. The ratio of Lyt2+ and L3T4+ T cell subsets was measured by flow cytometry.</p><p><b>RESULTS</b>SMP stimulated obvious proliferation of mixed lymphocytes, showed protective effects on T lymphocyte and increased the ratio of Lyt2+ and L3T4+ cell subsets to nearly normal level in immunosuppressed mice.</p><p><b>CONCLUSIONS</b>SMP can regulate the immune function in mice.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polissacarídeos
/
Baço
/
Streptomyces
/
Linfócitos T
/
Linfócitos T CD4-Positivos
/
Química
/
Hospedeiro Imunocomprometido
/
Teste de Cultura Mista de Linfócitos
/
Biologia Celular
/
Alergia e Imunologia
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2008
Tipo de documento:
Artigo
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