Pancreatic enzymes in the gut contributing to lung injury after trauma/hemorrhagic shock / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 36-41, 2004.
Artigo
em Inglês
| WPRIM
| ID: wpr-270283
ABSTRACT
<p><b>OBJECTIVE</b>To examine whether pancreatic proteolytic enzymes involve in lung injury induced by trauma/hemorrhagic shock (T/HS).</p><p><b>METHODS</b>Male Sprague-Dawley rats received intraluminal or intravenous pancreatic serine protease inhibitor, 6-amidino-2-naphthyl p-guanidinobenzoate dimethanesulfate (ANGD) during laparotomy (trauma), and were subjected to 90 minutes of T/HS or trauma-sham shock (T/SS). Degree of lung injury was assessed 3 hours after resuscitation with Ringer's lactate solution.</p><p><b>RESULTS</b>Lung permeability, pulmonary myeloperoxidase levels and the ratio of bronchoalveolar lavage fluid protein to plasma protein increased after T/HS, and significantly decreased in intraluminal-ANGD treated but not in intravenous-ANGD treated rats. Histological analysis demonstrated fewer injured villi in the intraluminal-ANGD treated rats compared with those in the control rats. Linear regression analysis revealed that the percentage of injured ileal mucosal villi directly related to pulmonary polymorphic neutrophil sequestration and lung permeability to Evans blue dye.</p><p><b>CONCLUSIONS</b>Pancreatic proteolytic enzymes in the ischemic gut may be important toxic factors contributing to lung injury after T/HS.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Choque Hemorrágico
/
Injeções Intralesionais
/
Escala de Gravidade do Ferimento
/
Inibidores de Serina Proteinase
/
Probabilidade
/
Fatores de Risco
/
Análise de Variância
/
Sensibilidade e Especificidade
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Journal of Traumatology
Ano de publicação:
2004
Tipo de documento:
Artigo
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